24 de agosto de 2010
Mestrado Antonio Reis-Caracterização dos SOC em pacientes com Esquizofrenia
16 de junho de 2010
CNS Spectr. 2008 May;13(5):425-32.
Sensory phenomena in obsessive-compulsive disorder and tic disorders: a review of the literature.
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Prado HS, Rosário MC, Lee J, Hounie AG, Shavitt RG, Miguel EC.
Department of Psychiatry at the University of São Paulo Medical School, São Paulo, Brazil. pradohelena@gmail.com
Abstract
INTRODUCTION: A variety of subjective experiences have been reported to be associated with the symptom expression of obsessive-compulsive disorder (OCD) and Tourette syndrome (TS). First described in TS patients, these subjective experiences have been defined in different ways. There is no consensus in the literature on how to best define subjective experiences. This lack of consensus may hinder the understanding of study results and prevents the possibility of including them in the search for etiological factors associated with OCD and TS. METHODS: The objective of this article was to review the descriptions of subjective experiences in the English-language literature from 1980-2007. This meta-analytic review was carried out using the English-language literature from 1980-2007 available on MEDLINE, PsycINFO, and the Cochrane Library databases using the following search terms: premonitory urges, sensory tics, “just-right” perceptions, sensory phenomena, sensory experiences, incompleteness, “not just-right” phenomena, obsessive-compulsive disorder and TS, including OCD and/or TS, in all combination searches. We also searched for the references cited in each article previously found that referred to the aforementioned terms. Thirty-one articles were included in the study. RESULTS: Subjective experiences, in particular, the sensory phenomena, were important phenotypic variables in the characterization of the tic-related OCD subtype and were more frequent in the early-onset OCD subtype. There is a paucity of studies using structured interviews to assess sensory phenomena, their epidemiology and the etiological mechanisms associated with sensory phenomena. CONCLUSION: The current review provides some evidence that sensory phenomena can be useful to identify more homogenous subgroups of OCD and TS patients and should be included as important phenotypic variables in future clinical, genetic, neuroimaging, and treatment-response studies.
Pediatrics. 2008 Nov;122(5):1157; author reply 1157-8.
The role of group A beta-hemolytic streptococcal infection in neuropsychiatric disorders.
de Alvarenga PG, Hounie AG, Miguel EC.
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Anxiety disorders and rheumatic Fever: is there an association?
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Seixas AA, Hounie AG, Fossaluza V, Curi M, Alvarenga PG, De Mathis MA, De Mathis ME, Vallada H, Pauls D, de Bragança Pereira CA, Miguel EC.
Department of Psychiatry, University of São Paulo Medical School, Brazil. anah@protoc.com.br
Abstract
INTRODUCTION: Findings suggest that obsessive-compulsive disorder (OCD) and related disorders, referred to as obsessive-compulsive spectrum disorders (OCSDs), are more common in patients with rheumatic fever (RF). OBJECTIVES: To determine whether RF or Sydenham’s chorea increases the probability of anxiety disorders in the relatives of individuals with RF with and without SC. METHODS: This was a case-control family study in which 98 probands and 389 first-degree relatives (FDRs) were assessed using structured psychiatric interviews. A Poisson regression model was used to determine whether the presence of any disorder in one family member influences the rate of disorders in the remaining family members. RESULTS: Generalized anxiety disorder (GAD) occurred more frequently in the FDRs of RF probands than in those of control probands (P=.018). The presence of RF, GAD, or separation anxiety disorder in one family member significantly increased the chance of OCSDs in another member of the family. CONCLUSION: We found familial aggregation among RF, GAD, and OCSDs. Clinicians should be aware of the possible familial relationship between GAD and OCSDs in their RF patients and their family members, which may suggest a genetic component between them. Further studies on OCD should include anxiety disorders to better define OCD spectrum.
Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder
Rev Bras Psiquiatr. 2009 Jun;31(2):131-5.
Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder.
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Cordeiro Q, Cappi C, Sampaio AS, Palácios SA, Pereira CA, Shavitt RG, Miguel EC, Guilherme L, Hounie AG.
Department and Institute of Psychiatry, Medical School, Universidade de São Paulo, São Paulo, SP, Brazil.
Abstract
OBJECTIVE: Evidence from family and molecular genetic studies support the hypothesis of involvement of immunologic mechanisms in the pathophysiology of obsessive-compulsive disorder. The nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 (NFKBIL1) has been suggested as a modulator of the immunological system. Given the importance of NFKBIL1 in the immunological response, the present study investigated the -62A/T polymorphism (rs2071592), located in the promoter region of its gene (NFKBIL1), as a genetic risk factor for the development of obsessive-compulsive disorder. METHOD: The -62A/T NFKBIL1 polymorphism was investigated in a sample of 111 patients who met DSM-IV criteria for obsessive-compulsive disorder and 272 healthy age- and gender-matched controls. RESULTS: There were no differences in genotypic distributions between patients and controls (chi2 = 0.98; 2 d.f.; p = 0.61). DISCUSSION: Despite these negative findings, more comprehensive polymorphism coverage within the NFKBIL1 is warranted in larger samples. Populations with different ethnic backgrounds should also be studied. CONCLUSION: The results of the present investigation do not provide evidence for the association between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder in this Brazilian sample.
Pesquisa: pacientes com TOC virgens de tratamento. Quais as suas características?
Rev Bras Psiquiatr. 2009 Dec;31(4):349-53.
The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description.
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Hoexter MQ, Shavitt RG, D’Alcante CC, Cecconi JP, Diniz JB, Belotto-Silva C, Hounie AG, Borcato S, Moraes I, Joaquim MA, Cappi C, Sampaio AS, Mathis MA, Batistuzzo MC, Lopes AC, Rosa AC, Muniz RK, Marques AH, Santos LC, Taub A, Duran FL, Dougherty DD, Busatto GF, Bressan RA, Miguel EC.
Department & Institute of Psychiatry, Clinical Hospital, Medical School, Universidade de São Paulo, São Paulo, SP, Brazil.
28 de maio de 2010
Terapia Comportamental para tiques
20 de março de 2010
Dissertação Mestrado Alice De Mathis-Características fenotípicas do transtorno obsessivo-compulsivo com idade de início precoce dos sintomas
17 de março de 2010
11 de março de 2010
Mudanças nos critérios diagnósticos do TOC
Atualmente os critérios diagnósticos para o TOC de acordo com o DSM-IV exigem que o indivíduo afetado tenha obsessões e compulsões, que estas sejam reconhecidas como exageradas ou sem sentido, que ocupem pelo menos uma hora por dia e que não se devam a uma condição médica geral. O Prof Euripedes Miguel faz parte de um grupo de autores que trabalha na revisão dos diagnósticos para TOC no futuro DSM-V, o qual se espera fique pronto em dois anos. Entre as alterações sugeridas estão: 1- esclarecer o conceito de obsessão e compulsão; 2-sugerir a remoção do critério que exige o reconhecimento de que as obsessões sejam excessivas ou sem sentido; 3-repensar o item de interferência na vida do individuo, por exemplo, reformulando o critério de “gasto de tempo”com o TOC; 4-adicionar mais transtornos para ajudar no diagnóstico diferencial; 5-redefinir o que seria uma condição médica geral que, teoricamente, não poderia ser a causa do TOC; 6-revisar os especificadores, por exemplo, acrescentar que o TOC pode ter graus variados de insight além de adicionar um subtipo de TOC ligado a tiques; 7- acrescentar ao texto características clínicas que não figuram no atual DSM-IV.
Essas mudanças objetivam tornar o diagnóstico mais claro e facilitar tanto o clínico como os pesquisadores na área. Abaixo, encontra-se a referência do artigo que se encontra em processo de publicação.
Obsessive-compulsive disorder: a review of the diagnostic criteria and possible subtypes and dimensional specifiers for DSM-V.Leckman JF, Denys D, Simpson HB, Mataix-Cols D, Hollander E, Saxena S, Miguel EC, Rauch SL, Goodman WK, Phillips KA, Stein DJ. Depress Anxiety. 2010 Mar 9. [Epub ahead of print]
7 de fevereiro de 2010
Tese Doutorado Ana Hounie-Transtornos do espectro obsessivo-compulsivo e febre reumática: um estudo de transmissão familiar
Tese Doutorado Marcos Mercadante-TRANSTORNO OBSESSIVO-COMPULSIVO, TIQUES, SÍNDROME DE TOURETTE E OUTROS TRANSTORNOS PSIQUIÁTRICOS EM PACIENTES COM FEBRE REUMÁTICA, COM OU SEM CORÉIA DE SYDENHAM
Tese Doutorado Ygor Ferrão-Características clínicas do transtorno obsessivo-compulsivo refratário aos tratamentos convencionais.
Tese Doutorado Roseli G Shavitt-Fatores preditivos de resposta ao tratamento em pacientes com o transtorno obsessivo-compulsivo
Tese de Doutorado – Maria Conceição do Rosário-Estudo genético familiar de crianças e adolescentes com transtorno obsessivo-compulsivo
22 de novembro de 2009
Drauzio Varella entrevista Dra Ana Hounie sobre síndrome de Tourette
